Focus–Adverse Response Interactions There's a relationship concerning escalating oxycodone plasma focus and increasing frequency of dose-relevant opioid adverse reactions such as nausea, vomiting, CNS effects, and respiratory melancholy.
The concomitant use of PERCOCET with all cytochrome P450 3A4 inhibitors may possibly lead to a rise in oxycodone plasma concentrations, which could maximize or prolong adverse reactions and should induce perhaps lethal respiratory depression.
Opioid antagonists, for example naloxone, are distinct antidotes to respiratory melancholy ensuing from opioid overdose. For clinically considerable respiratory or circulatory despair secondary to opioid overdose, administer an opioid antagonist. Since the duration of opioid reversal is expected to be less than the duration of action of oxycodone in PERCOCET, thoroughly keep an eye on the affected individual until eventually spontaneous respiration is reliably reestablished.
Accidental ingestion of oxycodone and acetaminophen tablets, In particular by kids, can lead to respiratory depression and Demise because of an overdose of oxycodone and acetaminophen tablets.
Animal reproductive reports haven't been performed with oxycodone and acetaminophen tablets. It is additionally not recognised no matter if oxycodone and acetaminophen tablets might cause fetal harm when administered to the Expecting woman or can impact reproductive ability.
Never use with any other drug containing acetaminophen without inquiring your physician or pharmacist very first. Acetaminophen is in lots of nonprescription and prescription drugs (for instance pain/fever medications or cough-and-cold items).
Propulsive peristaltic waves from the colon are read more reduced, when tone could be increased to The purpose of spasm, resulting in constipation. Other opioid-induced outcomes might include a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.
INDICATIONS AND Utilization PERCOCET is indicated to the management of pain intense plenty of to need an opioid analgesic and for which different remedies are insufficient.
78 times the MHDD (based upon a overall body area comparison) and there was a reduction in the quantity of mating pairs generating a fifth litter at this dose, suggesting the opportunity for cumulative toxicity with Serious administration of acetaminophen near the higher Restrict of everyday dosing.
PERCOCET is: A powerful prescription suffering drugs that contains an opioid (narcotic) that is definitely made use of to manage discomfort, serious sufficient to require an opioid analgesic and for which different treatment plans are inadequate and when other suffering treatment plans such as non-opioid discomfort medicines usually do not deal with your suffering well plenty of or You can't tolerate them.
PERCOCET shouldn't be provided to the Expecting female Except within the judgment in the physician, the prospective Rewards outweigh the achievable hazards.
The risk of acute liver failure is larger in people today with underlying liver sickness and in individuals who ingest alcohol when getting acetaminophen.
Examine for indications of opioid withdrawal. If a CYP3A4 inducer is discontinued, contemplate PERCOCET dosage reduction and Appraise patients at frequent intervals for indications of respiratory melancholy and sedation.
Should you be employing a liquid type of this medication, utilize a medication measuring system to diligently evaluate the prescribed dose. Tend not to use a house spoon since you might not get the proper dose.